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不同抗生素治疗下呼吸道疾病的临床效价分析

Analysis of Clinical Efficacy of Different Antibiotics in the Treatment of Lower Respiratory Diseases

药学研究 / 2020,2(2)：45-51 / 2020-06-28 1161 1951

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• 作者： 王骏     
• 单位：

   阜阳市人民医院，阜阳

• 关键词： 抗生素；治疗方案；下呼吸道感染；医学探析
• Antibiotics; Treatment plan; Lower respiratory tract infection; Medical analysis
• 摘要： 目的：探讨 4 种治疗下呼吸道感染的抗生素方案，采用小成本法分析 每种方案的临床疗效和成本，为临床用药提供参考。方法：随机抽取该院收治 的下呼吸道感染的患者 120 例，排除不符合标准的患者，随机分为 A、B、C、 D4 个小组，年龄在 17—60 岁之间不等，平均年龄为（38.5±21.5）岁。4 组患 者将分别对应使用头孢曲松钠、头孢唑肟钠、阿奇霉素和左氧氟沙星 4 种抗生 素进行治疗，观察 4 种抗生素对患者的疗效及经济性。结果：经过治疗，4 组患 者在临床的疗效和不良反应等方面比较，差异无统计学意义（p ＞ 0.05）。但是 从经济方面，头孢曲松钠和左氧氟沙星在治疗效果显著的情况下，经济性明显 要优于头孢唑肟钠、阿奇霉素，相比另之下差异有统计学意义（p ＜ 0.05）。结 论：通过对 4 组患者的临床治疗，发现头孢曲松钠和左氧氟沙星者 2 种抗生素的性价比更高。所以在选择治疗下呼吸道感染的药物时，应该选择疗效和成本 兼优的头孢曲松钠和左氧氟沙星。
• Objective: To explore four antibiotic regimens for the treatment of lower respiratory tract infection, and analyze the clinical efficacy and cost of each regiment by using the small cost method, so as to provide reference for clinical medication. Methods: A total of 120 patients with lower respiratory tract infection were randomly selected from the hospital, and those who did not meet the criteria were excluded. They were randomly divided into four groups: A, B, C and D, the age ranged from 17 to 60 years old, with an average age of (38.5 ± 21.5) years. Four kinds of antibiotics, ceftriaxone sodium, ceftizoxime sodium, azithromycin and levofloxacin, were used to treat the four groups of patients respectively. Results: After treatment, there was no significant difference between the four groups in clinical efficacy and adverse reactions (p > 0.05). However, in terms of economy, the economy of ceftriaxone sodium and levofloxacin is significantly better than that of ceftizoxime sodium and azithromycin when the therapeutic effect is significant (p < 0.05). Conclusion: Through the clinical treatment of four groups of patients, we found that ceftriaxone sodium and levofloxacin were more cost-effective. Therefore, ceftriaxone sodium and levofloxacin with excellent efficacy and cost should be selected in the treatment of lower respiratory tract infection.
• DOI： https://doi.org/10.35534/rp.0202006c
• 引用： 王骏．不同抗生素治疗下呼吸道疾病的临床效价分析［J］．药学研究，2020，2（2）：45-51．