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N-乙酰半胱氨酸联合布地奈德/ 福莫特罗治疗慢性阻塞性病合并支气管扩张稳定期患者外周血T 细胞群、CRP、PTC 的影响

Effect of N-acetylcysteine Combined with Budesonide / Formoterol on T Cell Group, CRP and PTC in Peripheral Blood of Patients with Chronic Obstructive Disease and Bronchiectasis

Research on Pharmacology / 2020,2(3): 77-87 / 2020-08-31 758 728

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• Authors: 曾德文*      李冬梅      何顺平      吴伟英      袁会清      刘志锋      黄江     
• Information:

  韶关市第一人民医院，韶关

• Keywords: Bronchiectasis-COPD overlap; Budesonide/formoterol; N-Acetyl-Lcysteine; T cell; CRP; PTC 布地奈德/ 福莫特罗；慢性阻塞性肺病合并支气管扩张；N- 乙酰半胱 氨酸；T 细胞；CRP；PTC
• Abstract: Objective: To evaluate the effect of N-acetylcysteine combined with budesonide / formoterol on peripheral blood T cell group, C-reactive protein and procalcitonin in patients with chronic obstructive disease and bronchiectasis. Methods: 38 patients with stable BCO after acute attack were divided into two groups: the combination group and the conventional group. Both groups were treated with budesonide / formoterol inhaler, and the combination group was treated with N-acetylcysteine at the same time for three courses. Lung function, CD4+, CD8+, CRP and PTC were analyzed before and after treatment. Results: (1) The FEV1 and the levels of CD4+ / CD8+, CRP and PTC in BCO patients were significantly improved by the two methods; (2) Compared with the conventional group, the improvement of CD4+ and CD8+ in peripheral blood in the combined group was significant. Conclusion: Compared with budesonide / formoterol alone, combination of N-acetylcysteine and budesonide / formoterol can effectively improve the systemic inflammatory response in the stable period of BCO, enhance its immunity and anti infection ability, and have better clinical effect. 目的：探讨N- 乙酰半胱氨酸联合布地奈德/ 福莫特罗在治疗慢性阻 塞性病合并支气管扩张患者的临床效果及其对外周血T 细胞群、C 反应蛋白、 降钙素原的水平的影响。方法：因急性发作入院治疗后处于稳定期的BCO 患者 38 人，随机分为联合用药组和常规用药组，所有患者均使用布地奈德/ 福莫特罗， 其中联合用药组同时使用N- 乙酰半胱氨酸，治疗3 疗程，在治疗前和治疗后 进行肺功能、CD4 ＋、CD8 ＋、CRP 和PTC 的分析检测。结果：（1）两种用药 方式均能显著提升BCO 患者的FEV1，显著降低CD4 ＋ /CD8 ＋、CRP 和PTC水平；（2）与常规组相比，联合用药组外周血CD4 ＋、CD8 ＋的改善程度显著。 结论：联合N- 乙酰半胱氨酸联合布地奈德/ 福莫特罗比独单使用布地奈德/ 福 莫特罗相，更能有效改善BCO 稳定期的全身性炎症反应，提升其免疫和抗感染 能力，具有更佳的临床疗效。
• DOI: https://doi.org/10.35534/rp.0203011
• Cite: 曾德文，李冬梅，何顺平，等．N- 乙酰半胱氨酸联合布地奈德/ 福莫特罗治疗慢性阻塞性病合并支气管扩张稳定期患者外周血T 细胞群、CRP、PTC 的影响［J］．药学研究，2020，2（3）：77-87．