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Environment and Resource
ISSN Print:2707-2398
ISSN Online:2707-2401
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可持续视角下多肽修饰药物载体的绿色设计、环境优化与风险调控研究
Research on Green Design, Environmental Optimization and Risk Regulation of Peptide-modified Drug Carriers from a Sustainable Perspective
- Authors: 方宝 周光旭 刘敏 易旭东
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Information:
太极集团重庆涪陵制药厂有限公司，重庆
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Keywords:
Peptide; Drug carrier; Green synthesis; Biodegradability; Sustainability多肽; 药物载体; 绿色合成; 可持续性
- Abstract: Peptide-modified drug carriers represent not only a cutting-edge drug delivery platform but also, due to their molecular-level programmability, a key technology for achieving green pharmaceuticals and sustainable healthcare. Building on the investigation of their traditional advantages—such as enhanced drug targeting, biocompatibility, and controlled release—this study emphasizes the integration of environmental science and sustainability perspectives. We systematically elaborate on how rational peptide sequence design can simultaneously optimize the therapeutic performance and environmental friendliness of carriers. This includes utilizing renewable raw materials, designing predictable environmental degradation pathways, and reducing the environmental footprint of synthesis processes. The paper provides an in-depth analysis of the potential environmental fate and ecological risks faced by peptide-modified carriers after emission and proposes a life-cycle environmental impact assessment framework. By integrating data on therapeutic efficacy, in vivo safety, and ecotoxicology, a multidimensional evaluation system is constructed. Finally, addressing a series of challenges from synthesis to environmental fate, this paper envisions the broad prospects of peptide-based carriers at the intersection of precision therapy and environmental sustainability, highlighting their future potential in reducing the overall ecological burden of healthcare systems and advancing the circular economy. 多肽修饰的药物载体不只是充当前沿的药物递送平台，更因为其在分子层面表现出的可编程特质，成为实现绿色制药及可持续医疗的关键技术之一，本研究以探究其增强药物靶向性、生物相容性，以及可控释放等传统优势为基础，重点将环境科学与可持续性视角引入。系统介绍了如何依托多肽序列的理性构思，同步增进载体的治疗效果与环境友好水平，包括借助可再生原料、设计可评估的环境降解路径，以及降低合成环节的环境损耗，透彻分析了多肽修饰载体排放后可能会面临的环境归宿及生态风险问题，给出了覆盖全生命周期的环境影响评估架构。通过整合治疗作用效果、体内安全情况及生态毒理学数据，构建起多维度的评估体系，面对从合成到环境归宿的系列挑战，对多肽载体在精准治疗与环境可持续发展交叉领域展现的广阔前景进行展望，指出其未来在降低医疗系统整体生态负荷、实现循环经济方面有极大潜力。
- DOI: https://doi.org/10.35534/er.0702026 (registering DOI)
- Cite: 方宝，周光旭，刘敏，等．可持续视角下多肽修饰药物载体的绿色设计、环境优化与风险调控研究［J］．环境与资源，2025，7（2）：311-316.
