International Open Access Journal Platform

Twist调控人胃癌组织中的上皮间质转化和血管生成拟态作用机制研究

Investigation of the Mechanisms by which Twist Regulates Epithelial-mesenchymal Transition and Vasculogenic Mimicry in Human Gastric Cancer Tissues

Frontiers of Clinical Medicine / 2024,6(1): 1-10 / 2024-01-24 544 586

View Download PDF

• Authors: 于淇¹      张兆堃¹      鄂思含¹      李露露²      徐万鹏³     
• Information:

  1. 山东第二医科大学临床医学院，潍坊；
  2. 山东第二医科大学附属医院病理科，潍坊；
  3. 山东第二医科大学附属医院胃肠肛门疾病外科，潍坊

• Keywords: EMT; Twist; Invasion, Correlation EMT；Twist；侵袭；相关性
• Abstract: Objective: The aim of this study was to investigate the role of Twist in promoting Vasculogenic Mimicry, thereby enriching and enhancing the theory of vasculogenic mimicry. Methods: The expression of Twist, Epithelialmesenchymal Transition markers (E-cadherin and Vimentin), and VM marker CD34-PAS were observed in gastric carcinoma tissues and normal gastric tissues. The correlation between Twist, EMT markers, and clinical pathological features of gastric carcinoma was analyzed. The relationship between VM and EMT markers, as well as Twist and EMT markers, was studied. Furthermore, the involvement of Twist in promoting gastric carcinoma EMT and VM formation was validated. Results: Significant differences were observed in the expression of EMT markers (E-cadherin and Vimentin) and VM marker CD34-PAS. Twist showed a certain correlation with EMT markers. Conclusion: Twist may induce EMT in gastric carcinoma cells and promote the formation of VM in gastric carcinoma. Note The translation provided aims to align with the language style typically used in scientific publications. 目的：研究Twist促进VM的形成，丰富和完善了血管生成拟态理论。方法：观察胃癌组织及正常胃组织Twist、EMT标志蛋白（E-cadherin和Vimentin）及VM标记物CD34-PAS的表达情况，分析Twist、EMT标志蛋白与胃癌临床病理特征的相关性，研究VM与EMT标志蛋白的关系，Twist与EMT标志蛋白的关系。进一步验证Twist通过促进胃癌EMT、从而促进VM的形成结果：EMT标志蛋白和VM有统计学差异，Twist及EMT标志蛋白有一定的相关性。结论：Twist可能诱导胃癌细胞EMT的发生，并促进胃癌VM的形成。
• DOI: https://doi.org/10.35534/fcm.0601001
• Cite: 于淇，张兆堃，鄂思含，等．Twist调控人胃癌组织中的上皮间质转化和血管生成拟态作用机制研究［J］．临床医学前沿，2024，6（1）：1-10.