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Authors:
纪月娥
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Information:
湖北工业大学,武汉
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Keywords:
Solution headspace gas chromatography; Wide bore capillary column; Residual organic solvent; Artemether
液体顶空气相色谱法; 大口径毛细管柱; 有机溶剂残留; 蒿甲醚
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Abstract:
A solution headspace gas chromatography for the determination of residual
organic solvent in Artemether was established. A DB-1 wide bore capillary column
was used with Referencel standard. The linear range for methanol, ethanol and
dichloromethane were 30.2~635.2μg·mL -1 (r=0.9991), 6.4~64.5μg·mL -1 (r=0.9991) and
5.5~68.7μg·mL -1 (r=0.9990) respectively. The average recoveries of methanol, ethanol
and dichloromethane were 99.9%, 103.8%and 99.3%respectively. The lowest test
limits of methanol , ethanol and dichloromethane were 0.02μg·g -1 , 0.04 μg·g -1 and
0.01μg·g -1 ,respectively. The method was simple, accurate, sensitive and repeatable.
建立了液体顶空气相色谱法测定蒿甲醚中有机溶剂残留量。采用 DB-1
大口径毛细管柱,以对照品作外标进行定量。甲醇、乙醇及二氯甲烷的线性范
围分别为 30.2 ~ 635.2 μg·mL -1 (r=0.9991),6.4 ~ 64.5 μg·mL -1 (r=0.9991)
和 5.5 ~ 68.7 μg·mL -1 (r=0.9990);回收率分别为 99.9%,103.8% 和 99.3%;
检测限分别为 0.02 μg·g -1 ,0.04 μg·g -1 和 0.01 μg·g -1 。本方法简单、准确、
灵敏度及重现性好。
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DOI:
https://doi.org/10.35534/macr.0202010c
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Cite:
纪月娥.基于液体顶空气相色谱法的蒿甲醚中有机溶剂的残留测定[J].现代分析化学研究,2020,2(2):63-69.