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精神分裂症患者的谷氨酸水平与社会认知相关关系的综述研究

A Review of the Correlation between Glutamate Levels and Social Cognition in Patients with Schizophrenia

Psychology of China / 2022,4(9): 1001-1008 / 2022-09-16 821 502

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• Authors: 陈思宇
• Information:

  西南交通大学希望学院，成都

• Keywords:
  Schizophrenia; Social cognition; Glutamate; Magnetic resonance spectroscopy
  精神分裂症; 社会认知; 谷氨酸; 磁共振波谱成像
• Abstract: Patients with schizophrenia exhibited various social cognitive deficits. According to the glutamate hypothesis, these social cognitive deficits might be the result of glutamatergic dysfunction in the brain. In-vivo glutamate levels could be detected by the Magnetic Resonance Spectroscopy. Magnetic Resonance Spectroscopy studies conducted in the general individuals, individuals with high risk of schizophrenia, and patients with autism spectrum disorders indicated that glutamate levels may be correlated with social cognition in patients with schizophrenia. Correlations between glutamate levels and different social cognition could be further explored in patients with schizophrenia and the subclinical individuals in the future. 精神分裂症患者存在广泛的社会认知缺陷。根据“谷氨酸假说”，这些社会认知缺陷可能是脑内谷氨酸水平异常的结果。采用磁共振波谱成像技术可以探测大脑中的谷氨酸水平。在一般人群、精神分裂症高危人群、孤独症患者中的磁共振波谱成像研究，提示精神分裂症患者的谷氨酸水平与社会认知可能存在相关。未来可在精神分裂症患者和亚临床群体中进一步探究谷氨酸水平与多种社会认知的相关关系。
• DOI: https://doi.org/10.35534/pc.0409119
• Cite: 陈思宇．精神分裂症患者的谷氨酸水平与社会认知相关关系的综述研究［J］．中国心理学前沿，2022，4（9）：1001-1008．