Abstract:
Neuropsychiatric symptoms ralated to negative emotions, such as anxiety and depression,
are a key indicator of early identification and early intervention for elderly people with mild cognitive
impairment. In this paper, the neuropsychiatric symptoms related to mood in MCI and MCI subtypes,
and the relationship between anxiety, depression, MCI and dementia are reviewed. It is believed that
the relationship between anxiety, depression and MCI is reciprocal, and both of them can accelerate the
process of MCI or MCI subtypes to dementia. In the future, the research direction can not only be limited
to the attention on the behavioral indicators of the negative emotions among older adults with MCI or
dementia, but also can be combined with the biomarker indicators for comprehensive identification and
intervention, improving the daily emotional experience and quality of life among aging populations.
与负性情绪相关的神经精神症状,如焦虑和抑郁,是轻度认知障碍个体早期识别和干预的一个重要指标。本文系统梳理了轻度认知障碍及其亚型群体的神经精神症状以及焦虑和抑郁与轻度认知障碍及痴呆之间关系的研究进展。发现焦虑和抑郁情绪与轻度认知障碍及其亚型之间是相互作用的关系,并且二者均会加速轻度认知障碍及其亚型向痴呆转化的进程。未来的研究方向不仅仅可以局限于对轻度认知障碍群体负性情绪行为学上的关注,还可以结合神经生物学指标对情绪进行综合地识别和干预,以此改善轻度认知障碍个体的日常情绪体验和生活质量。